Instead, in southern Europe, a distinct hunter-gatherer genetic profile was found as early as 17ka in individuals associated with the Epigravettian culture15 (2412ka, from the Italian peninsula to the southeastern European Plain across the Balkans). & Zimmermann, A. Publication: Huang T, Reimand J. Network-rewiring mutation in kinase signaling networks are informative of cancer patient. Fu, Q. et al. PACEA co-authors of this research benefited from the scientific framework of the University of Bordeauxs IdEx Investments for the Future programme/GPR Human Past. Advanced Science: Vol 10, No 7 - onlinelibrary.wiley.com The youngest individual carrying large portions of hunter-gatherer ancestry in the analysed dataset is from Ostorf in northern Germany, dated to around 5.2ka (>90% Oberkassel clusterplus Sidelkino-clustercomponents)(Supplementary Data 3.F). use of cookies Contrary to the proposal in Fu et al.4 but in agreement with Petr et al.17, we do not observe a substantial decrease of Neanderthal ancestry in most European hunter-gatherers through time (Supplementary Information, section6 and Supplementary Figs. There is no biographical data to display. This might also explain the genetic uniformity of the Oberkassel cluster across large parts of western Eurasia but genomic data from between 15 and 14ka is needed to understand the exact dynamics of this turnover. Big Data, Data Mining, and Machine Learning (Jared Dean) . In the first place, we have traditional analysis. Fu, Q. et al. I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. These data cover a time span of around 30,000 years from the Upper Palaeolithic to the Late Neolithic (defined here by the presence of pottery rather than by farming subsistence economy if not indicated), derive from multiple prehistoric cultural contexts, and originate from 54 archaeological sites in 14 countries: 1 Aurignacian-associated individual from Belgium and 1 culturally unassigned individual from Romania (3533ka), 15 Gravettian-associated individuals from Spain, France, Belgium, Czechia and Italy (3126ka), 2 Solutrean-associated individuals from Spain and France (2321ka), 9 Magdalenian-associated individuals from France, Germany, and Poland (1815ka), 4 Epigravettian-associated individuals from Italy (1713ka), 2 Federmesser-associated individuals from Germany (14ka), and 81 Mesolithic to Neolithic foragers from across western Eurasia (115ka), together with 1 central Eurasian Neolithic individual from Tajikistan (8ka) (Fig. Archaeological background, method descriptions and discussions additional to the main text, including sections 113, Figs. It was awesome seeing the thought process behind each of the questions - it helps students immensely! It requires countless decisions to get them right, many of which have not been as straightforward at first. Ice Age survivors -- ScienceDaily El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). In this debated framework, Gravettian-associated individuals have been suggested to represent a biologically homogeneous population on the basis of craniometric and genomic data4,22. & Meyer, M. Extraction of highly degraded DNA from ancient bones, teeth and sediments for high-throughput sequencing. In sum, we describe the formation and interaction between the Oberkassel and Sidelkino clusters, the two main hunter-gatherer ancestries present in Europe from 14ka onwards. This was confirmed with qpAdm, in which we could model all individuals from the Oberkassel cluster as a broadly constant mixture of approximately 75% Arene Candide 16 and 25% Goyet Q-2 (or 90% Arene Candide 16 and 10% Fournol 85) (Fig. We generated genome-wide sequencing data for 102 newly reported hunter-gatherers, and increased coverage for 14 previously published individuals4. Tina has an MSc in Computer Science from the University of Pennsylvania, and an HBSc in Pharmacology from the University of Toronto. Trans. Nat. Olalde, I. Data warehousing is a field where you often have to deal with a lot of raw data. Nature 505, 8791 (2014). Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness . 2010, pdb.prot5448 (2010). Jagwire Europe - Fevacom NV . 6 Reasons We Just Cant Stop. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Biol. Tina Huang I'm a data scientist, youtuber, and the first Lonely Octopus . This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka). TV Actresses. Her motto to live by is "Always minimize effort and maximize outcome!". Xinhe Huang - Teaching Assistant - Cardiff University / Prifysgol Riddle Solved: Why Was Roman Concrete So Durable? Soonafter8 ka, Sidelkino ancestry was absent in eastern Spain but it had already reached northern Iberia alongside an increase in Oberkassel ancestry (Fig. Tina Zhang - Brand Specialist - Dymind Biotechnology | ZoomInfo This figure shows that the Gravettian-associated individuals from western Europe (Fournol cluster) are closely related to Goyet Q116-1 while the Gravettian-associated individuals from central-eastern and southern Europe (Vstonice cluster) are closely related to the Sunghir group, representative of the Kostenki cluster. The analysis of biological relatedness was performed by calculating relatedness coefficient (r) based on PMR on the autosomal SNPs (Supplementary Data 1.F and Supplementary Information, section4). and H. Ringbauer developed the contamination-estimation method. de Lige, 2021). Meet Tina Huang. Google Scholar. 26 and Supplementary Data 2.H). Billed once. The deduplicated bam files were filtered using PMDtools 0.6068 with a threshold of 3, to reduce potential modern DNA contamination based on postmortem DNA deamination. Newsletter, I also have a newsletter called Boop's Keyboard! Nature 551, 368372 (2017). 1 and 2). An early modern human from Romania with a recent Neanderthal ancestor. The resulting GoyetQ2 cluster includes individuals spanning from western France to Poland in the period between 18 and 15ka. 40,000-year-old individual from Asia provides insight into early population structure in Eurasia. EAGER: efficient ancient genome reconstruction. We built a Maximum Parsimony tree with 103 mtDNA sequences plus an African sequence as the outgroup (not shown) after the removal of individuals younger than 6.5ka and mtDNAs from the same site with an identical placement. W jednej z historii misiaczki za rad pewnej wydry zamieszkuj w tajemniczym . She then served as a postdoctoral associate at the National Institute of Standards and Technology. Write for us- Weird Science, Energy & Minerals Guest Post. Echinacea, also known as Coneflower, is legendary for a reason: science has shown multiple species of Echinacea can provide potentially broad-reaching support for the innate and adaptive immune system. Science 360, 548552 (2018). Most Popular #86731. Curr. S. Shnaider received support from theRussian Science Foundation (no. of Leiden, 2000). Last Name Huang #8. de Investigacin en Arqueologa y Patrimonio Histrico, University of Alicante, Sant Vicent del Raspeig, Alicante, Spain, Javier Fernndez-Lpez de Pablo&Magdalena Gmez-Puche, Amsterdam Centre of Ancient Studies and Archaeology, University of Amsterdam, Amsterdam, The Netherlands, Department of Anatomy, Histology and Anthropology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Service Rgional de lArchologie de Bourgogne-Franche-Comt, Besanon Cedex, France, Laboratoire de Chrono-Environnement, UMR 6249 du CNRS, UFR des Sciences et Techniques, Besanon Cedex, France, Institute of Pre- and Protohistory, University of Tbingen, Tbingen, Germany, Department of Archeological Sciences, Thuringian State Office for Monuments Preservation and Archeology, Weimar, Germany, University of Bucharest, Faculty of Geology and Geophysics, Department of Geology, Bucharest, Romania, Institute for Advanced Studies in Levant Culture and Civilization, Bucharest, Romania, German Archaeological Institute, Berlin, Germany, Brandenburg Authorities for Heritage Management and Archaeological State Museum, Zossen, Germany, Institute for Pre- and Protohistory, Kiel University, Kiel, Germany, Institute of Archeology at Brno, Czech Academy of Sciences, Centre for Palaeolithic and Paleoanthropology, Brno, Czechia, Institute of Archaeology, Academy of Sciences of the Republic of Tatarstan, Kazan, Russia, Samara State University of Social Sciences and Education, Samara, Russia, Early Prehistory and Quaternary Ecology, Department of Geosciences, University of Tbingen, Tbingen, Germany, Paleoanthropology, Institute for Archaeological Sciences, Department of Geosciences, University of Tbingen, Tbingen, Germany, DFG Centre for Advanced Studies Words, Bones, Genes, Tools, University of Tbingen, Tbingen, Germany, Royal Belgian Institute of Natural Sciences, Brussels, Belgium, Institute of Archaeology Russian, Academy of Sciences, Moscow, Russia, School of Archaeology, University of Oxford, Oxford, UK, Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Sciences, Saint Petersburg, Russia, Department of Cultures, University of Helsinki, Helsinki, Finland, Seminar for Pre- and Protohistory, Gttingen University, Gttingen, Germany, Lower Saxony State Service for Cultural Heritage, Hannover, Germany, Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands, You can also search for this author in 27, 576582 (2017). My name is Tina Huang and Im a data scientist at a FAANG company. Jones, E. R. et al. First Name Tina. CAS TV Actress. This provides further support for the model with no long-term decline of genome-wide Neanderthal ancestry in modern humans following their introgression18. At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value. 12). Theyre both important sub-tasks for data scientists to master, but big data data warehousing and data science are only two components of the larger data science endeavor. The team analysed the genomes of 356 prehistoric hunter gatherers from different archaeological cultures -- including new data sets of 116 individuals from 14 different European and Central Asian countries. The bivariate plots show the expansion of Oberkassel and Sidelkino ancestries through time in two European areas (longitude below and above 30 degrees). Vallini, L. et al. Petr, M., Pbo, S., Kelso, J. CAS Late Upper Palaeolithic hunter-gatherers in the Central Mediterranean: new archaeological and genetic data from the Late Epigravettian burial Oriente C (Favignana, Sicily). Extended Data Fig. Genomic and dietary discontinuities during the Mesolithic and Neolithic in Sicily. Ruiz-Redondo, A. et al. Tina Huang (@hellotinah) / Twitter After DNA lysis, a subset of samples was extracted using silica-coated magnetic particles on an automated liquid handling system (Agilent Technologies Bravo NGS Workstation)57. Tina Huang - Climate & Environment Knowledge Analyst - LinkedIn Commun. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. Villalba-Mouco, V. et al. YourCourse Certificatehas no expiration date. Reads with a mapping quality below 30 were then filtered with samtools, and the consensus sequences were generated by Schmutzi69. The three squares highlight Baltic HG groups associated with the Comb Ceramic Culture (CCC) that show a marked increase in Sidelkino-related ancestrycompared to olderBaltic HG groups. The genetic history of Ice Age Europe. A.G.-O. I'm I've learned SQL before, but I need a refresher. Cassidy, L. M. et al. Archeol. For contaminated libraries we used the PMD-filtered bam files as the input for genotyping. This suggests that the newly reported Neolithic individual from central Asia carries an ancestry that might be a good proxy for the ANE-related contribution to Iran and the Turan region45 from around 5.5ka but not to roughly contemporaneous hunter-gatherers from eastern Europe. We further modelled the genetic profile of pre-LGM individuals with qpGraph (Supplementary Information, section10 and Supplementary Figs. 29, 11691177.e7 (2019). Big data data warehousing and data science are two sub-tasks of a larger endeavor called data science, which is a sub-tasks of data science. Sep 2017 - Aug 20181 year. . This article reviews qualitative and quantitative studies related to the academic achievement of youth from immigrant Chinese families. 359, 318 (2015). Therefore,most of the ancestry found in these post-LGM individuals probably traced back to Gravettian-associated groups from western and southwestern Europe. Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. Fu, Q. et al. First, I like it because of how powerful (almost magical) it is in driving decisions. Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. Youll be surprised how much value there is in a quick XGBoost model, for example. The LGM could thus have created a corridor south of the Alps for east-to-west human movements that genetically connected hunter-gatherer populations from the Balkans to Iberia, possibly also via dispersals along existing lower-sea-level coasts32. View Tina Zhang's business profile as Brand Specialist at Dymind Biotechnology. 2014-2020.4.01.16-0030) and C.L.S. Mittnik, A. et al. Y.H. 13). EY. Therefore, the broader terms archaeological culture or simply culture are used here to refer to archaeologically defined material cultures without implying links to modern anthropological and/or ethnographical concepts of culture. As long asyouget a exam score of 60% or above,youare eligible toreceive aCourse Certificate! Ecol. Quat. The genetic distinction between the Oberkassel and Sidelkino clusters is also clearly noticeable in the diversity of uniparentally inherited markers, as the Oberkassel cluster is dominated by mtDNA haplogroup U5 and Y-chromosome haplogroup I, whereas individuals from the Sidelkino cluster show a higher frequency of mtDNA haplogroups U2, U4 and R1b, and carry uniquely Y-chromosome haplogroups Q, R and J (Extended Data Figs. Gnther, T. et al. You are using a browser version with limited support for CSS. Palma di Cesnola, A. The phylogenetic reconstruction of Epigravettian-associated genomes, with Pradis 1 diverging more deeply than all others, indicates that the turnover took place much earlier than 17kathe date of the more derived Tagliente 2 genome. Alexis Bledel. By submitting a comment you agree to abide by our Terms and Community Guidelines. Notably, and contrary to the report by Fu et al.4, another Gravettian-associated population from centralwestern Europe (Goyet in Belgium, n=6 individuals) is both geographically and genetically intermediate between the Vstonice and Fournol clusters. Pseudo-haploid genotypes were called on the targeted SNPs by randomly sampling a single allele at each position, resulting in individuals with 6,600 to 1.07 million SNPs covered on the 1.24-million-SNP panel (Extended Data Table 1 and Supplementary Data 1.A). Villalba-Mouco, V. et al. We provide five novel insights into the genomic history of hunter-gatherer populations over a time span of 30,000 years from the Upper Palaeolithic to the Neolithic. I am Tina Huang, PhD, a data scientist, and the director of the Data Science Learning Center at the University of Arizona. Mounier, A. et al. Bioinformatics 25, 20782079 (2009). Both newly sequenced genomes from Solutrean-associated individuals (Le Piage II (23ka) from southwestern France and La Riera (level 14, 21ka) from northern Spain) show a generalized affinity with members of the Fournol and GoyetQ2 clusters in outgroup f3-statistics (Supplementary Data 2.A). I also have a newsletter called Boop's Keyboard! Nature 592, 253257 (2021). Mayra Alexandra Castrosqui - Quantitative Analyst - LinkedIn In conclusion, our study reveals that western and southwestern Europe served as climatic refugia for the persistence of human groups during the coldest phase of the last Ice Age whereas populations in the Italian peninsula and the eastern European plain were genetically overturned, challenging the role of these regions as glacial refugia for humans. Posth, C. et al. However, the level of genetic continuity between individuals associated with these cultures and the population structure among Epigravettian-associated individuals have not been fully explored. Nature 570, 182188 (2019). 2c). This affinity is even stronger towards Epigravettian-associated individuals from western and central Italy and Sicily (group 2 and group 3, respectively) than to those from northern Italy (group 1) (Supplementary Data 2.F). Finally, we estimated the genetic diversity of Epigravettian-associated individuals in the dataset by calculating both pairwise mismatch rates (PMR) on pseudo-haploid genotypes and individual heterozygosity levels on pseudo-diploid genotypes (Supplementary Data 3.A). Present-day individuals (gray dots) genotyped on theHumanOrigins dataset are used to define the PCA variation onto which ancient genomes (coloured symbols) are projected. 1c) and a west Eurasian principal component analysis (PCA) (Extended Data Fig. Wood, R. E. et al. and D.C. have received funding from the Italian Ministry of University and Research (MUR) PRIN 2017 grants 20177PJ9XF and 20174BTC4R_002. The cleaned reads with base quality and mapping quality over 30 were piled up with mpileup in SAMtools 1.373 on the 1240k targeted sites. 1 and 2). Interviewed Taiwanese designers and analyzed the interview data. Her channel is about data science, transitioning into computer science and software engineering. A 5700 year-old human genome and oral microbiome from chewed birch pitch. 10, 552010 (2019). Notably, the Fournol ancestry provides a better proxy than Goyet Q116-1 for the genetic component found in the GoyetQ2 cluster and in El Mirn (Supplementary Data 2.H). I'm a data scientist and youtuber. Subsequently, I worked in bioinformatics for a year and then did my Masters in computer science (MCIT) at the University of Pennsylvania. Mid and Late Upper Palaeolithic in the Adriatic Basin: chronology, transitions and human adaptations to a changing landscape. The average calibrated date is shown, with pie charts indicating the estimated proportion of ancestry for each group or individual. 4 and Supplementary Data 3.C). Ecol. https://doi.org/10.1038/s41586-023-05726-0, DOI: https://doi.org/10.1038/s41586-023-05726-0. Product development is, by far, my favorite data science use case for two main reasons. Tina K. Sorensen | Semantic Scholar Yu Ting Wang, Wen Lin Huang, Yan Ting Cheng. 272, 288296 (2012). Hajdinjak, M. et al. Known to have been the coldest phase of the last Ice Age, the LGM is considered to have caused a demographic decline in large parts of Europe10, with populations retracting to southern latitudes as attestedfor exampleby the contemporaneity of the Solutrean culture (2419ka) in the Iberian peninsula and southern France. (grey) of the f4 values estimated from 5cM-block jackknife analysis. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers,who were also characterized by marked differences in phenotypically relevant variants. a, Geographic locations of newly reported individuals (filled symbols with black outline) and representative previously published individuals (outlined stars). Article How to Become a Data Scientist at FAANG (Ft. Tina Huang) - Morioh "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. 8). received support from the Estonian Research Council grant PUT (PRG243). 2023 365 Data Science. Google Scholar. Second, the ancestry of individuals associated with the Epigravettian culture (Villabruna cluster), which was found to genetically connect European and Near Eastern hunter-gatherers, reached southern Europe well before the transition between the Early and Late Epigravettian4,15 and possibly as early as the GravettianEpigravettian transition. Djindjian, F. Territories and economies of hunter-gatherer groups during the last glacial maximum in Europe. The colours correspond to the grouping of tested populations, dots refer to the f4-values and the dark and light error bars to 1*SE and 3*SE estimated from 5 cM block jackknife, respectively.
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